Effectiveness of the neutralizing antibody sotrovimab among high-risk patients with mild-to-moderate SARS-CoV-2 in QatarArticle Published on 2022-11-012022-11-15 Journal: International Journal of Infectious Diseases [Category] SARS, 진단, [키워드] 95% confidence interval adjusted odds ratio Analysis BA.2 case-control study conducted Control control group controls COVID-19 COVID-19 severity Critical Disease progression drug Effectiveness eligible Epidemiology Evidence fatal COVID-19 food form high-risk patient higher risk incidence individual Mild-to-moderate neutralizing antibody occurred omicron Patient progression protective effect receive reducing SARS-CoV-2 Sotrovimab Sotrovimab. study period Subgroup analysis subgroup of patient Treatment treatment group United State [DOI] 10.1016/j.ijid.2022.09.023 PMC 바로가기
Utilization of the Abbott SARS-CoV-2 IgG II Quant Assay To Identify High-Titer Anti-SARS-CoV-2 Neutralizing Plasma against Wild-Type and Variant SARS-CoV-2 VirusesArticle Published on 2022-10-262022-11-15 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] 95% confidence interval Abbott Abbott SARS-CoV-2 IgG acute respiratory syndrome Analysis approach approach authorization BAU Beta binding antibody unit Canada CCP characterized Chicago Chicago IL clinical trial convalescent convalescent plasma coronavirus COVID-19 COVID-19 convalescent plasma Cutoff Delta disease course drug Emergency EUA evaluated Evidence experiment FDA food Gamma highest hospitalized patient Humoral immunity identify IgG immune IMPROVE Mann-Whitney U method comparisons Neutralization assay Neutralizing neutralizing antibody outcome Patient patient group plaque reduction neutralization plaque reduction neutralization. plasma PRNT quantitative determination required SARS-CoV-2 SARS-CoV-2 antibody selected significantly specimen tested the SARS-CoV-2 time-consuming treat United State utilization variant VLP VoC wild-type with COVID-19 [DOI] 10.1128/spectrum.02811-22 PMC 바로가기
Omicron Severe Acute Respiratory Syndrome Coronavirus 2 Neutralization by Immunoglobulin Preparations Manufactured From Plasma Collected in the United States and EuropeArticle Published on 2022-10-172022-11-15 Journal: The Journal of Infectious Diseases [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] acute respiratory syndrome antibody collected coronavirus coronavirus 2 coronavirus disease COVID-19 Donor Europe European Immunoglobulin Infection intravenous Intravenous immunoglobulin less neutralization Neutralizing Neutralizing antibodies new virus omicron pandemic plasma preparation Primary Immunodeficiency Prophylaxis Prophylaxis. proportion raising respiratory SARS-CoV-2 SARS-CoV-2 antibody SARS-CoV-2 antibody potency the United State union United State vaccination variant virus [DOI] 10.1093/infdis/jiac358 PMC 바로가기
Emergence of SARS-CoV-2 Omicron BA.5 variant of concern in Western Pennsylvania, United States미국 서부 펜실베니아에서 우려의 SARS-CoV-2 Omicron BA.5 변종 출현Article Published on 2022-10-012022-09-11 Journal: Journal of medical virology [Category] Coronavirus, COVID19(2023년), SARS, 변종, 치료법, [키워드] Abstract BA.4 BA.5 emergence omicron RT-PCR SARS-CoV-2 Sequencing sequencing. United State variant [DOI] 10.1002/jmv.27945 PMC 바로가기 [Article Type] Article
Neuropsychiatric sequelae of long COVID-19: Pilot results from the COVID-19 neurological and molecular prospective cohort study in Georgia, USAResearch article Published on 2022-10-012022-10-05 Journal: Brain, Behavior, & Immunity - Health [Category] 임상, [키워드] acute phase affected African American Analysis analyzed Anxiety appear average baseline Cognition cognitive Cohort Comorbidities Comorbidity Complete controls coronavirus coronavirus disease COVID-19 COVID-19 infection COVID-19 pandemic demographics demonstrated Depression dysfunction Evidence Health Hypogeusia Hyposmia Infection Long COVID measure Measures mental health molecular mononuclear cell neurologic neurological Neuropsychiatric pandemic participant Patient performed physical Population positive positive COVID-19 Prospective prospective cohort study Quantitative quantitative measurement recruit recruited reported Result scored self-reported symptom Self-reported symptoms severity Socioeconomic Factors study cohort Support Symptom these symptom United State USA White patient [DOI] 10.1016/j.bbih.2022.100491 [Article Type] Research article
First detection of SARS-CoV-2 Omicron BA.4 variant in Western Pennsylvania, United States미국 서부 펜실베니아주에서 SARS-CoV-2 Omicron BA.4 변종 첫 발견Article Published on 2022-09-012022-09-11 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 변종, 치료기술, 치료법, [키워드] omicron SARS-CoV-2 United State variant [DOI] 10.1002/jmv.27846 PMC 바로가기 [Article Type] Article
Impact of the COVID-19 Pandemic on Fecal Immunochemical Testing, Colonoscopy Services, and Colorectal Neoplasia Detection in a Large United States Community-based PopulationResearch article Published on 2022-09-012022-10-05 Journal: Gastroenterology [Category] 진단, 치료기술, [키워드] affected age Cancer Care changes in Colonoscopy Colorectal Colorectal cancer COVID-19 COVID-19 pandemic declined detection diagnosed diagnostic exceeded fecal fit Health help immunochemical Impact increase in investigated National neoplasia pandemic Patient performed Population positive Positive test reached reduction in Result resulting retrospective cohort study Screening Testing United State Volume [DOI] 10.1053/j.gastro.2022.05.014 [Article Type] Research article
A Glance at the Development and Patent Literature of Tecovirimat: The First-in-Class Therapy for Emerging Monkeypox OutbreakArticle Published on 2022-08-252022-11-15 Journal: Viruses [Category] Fulltext, 원숭이두창, 진단, 치료제, [키워드] animal antivirals approved benefit Canada clinical study COVID-19 development disease dosage drug drug combination drug resistance Efficacy EMA European Medicines Agency food forms Health Canada highlight infections injection Interaction literature literature review Monkeypox MOST non-human primate off-label orthopoxvirus outbreak parameters Patent patents. pharmacokinetic regulatory agency rule SIGA-246 technology tecovirimat TPOXX treat Treatment United State USA Viral diseases website [DOI] 10.3390/v14091870 PMC 바로가기
A validated LC-MS/MS method for determination of antiviral prodrug molnupiravir in human plasma and its application for a pharmacokinetic modeling study in healthy Egyptian volunteers인간 혈장에서 항 바이러스 전구 약물 Molnupiravir의 결정을위한 검증 된 LC-MS/MS 방법 및 건강한 이집트 자원 봉사자들의 약동학 적 모델링 연구에 대한 적용Article Published on 2022-08-152022-08-31 Journal: Journal of chromatography. B, Analytical technolog [Category] COVID19(2023년), MERS, SARS, 치료기술, 치료제, [키워드] acetic acetic acid acetonitrile Agilent analyte analyzed Antiviral approach AUC C max Concentration confidence interval detection determine develop dosage dose Eclipse Efficacy ESI evaluate extraction FDA flow rate geometric mean geometric mean ratios Geometric means GMR Guidance healthy healthy volunteer healthy volunteers Human plasma LC-MS/MS Linear regression linearity m/z mass spectrometer mass spectrometry maximum concentration metabolite mixture molnupiravir N-hydroxycytidine NHC pharmacokinetic pharmacokinetic data plasma Population Population Pharmacokinetic Modeling positive protein precipitation pumped recommendation required ribavirin SARS-CoV-2 SARS-CoV-2. Simulation solvent subjects therapeutic target therapeutic targets Treatment triple quadrupole mass spectrometer United State United States Volunteer was performed was used were used [DOI] 10.1016/j.jchromb.2022.123363 PMC 바로가기 [Article Type] Article
Trends of research productivity across author gender and research fields: A multidisciplinary and multi-country observational studyObservational Study Published on 2022-08-102022-10-04 Journal: PLoS ONE [Category] 임상, [키워드] analysed articles authors Canada comparable computer country declines decrease Effect Engineering England estimate examined female Gender Germany increase in investigated majority male males middle Middle East negatively affected Netherlands notable opposite over pandemic Potential relative growth Research researcher Science target trend United State USA while [DOI] 10.1371/journal.pone.0271998 PMC 바로가기 [Article Type] Observational Study